Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention
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چکیده
منابع مشابه
Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention.
Progressive fibrosis is a pathological hallmark of many chronic diseases responsible for organ failure. Although there is currently no therapy on the market that specifically targets fibrosis, the dynamic fibrogenic process is known to be regulated by multiple soluble mediators that may be therapeutically intervened. The failing hamster heart exhibits marked fibrosis and increased expression of...
متن کاملCALL FOR PAPERS Cellular Mechanisms of Tissue Fibrosis Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention
Mastri M, Shah Z, Hsieh K, Wang X, Wooldridge B, Martin S, Suzuki G, Lee T. Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention. Am J Physiol Cell Physiol 306: C531–C539, 2014. First published December 11, 2013; doi:10.1152/ajpcell.00238.2013.—Progressive fibrosis is a pathological hallmark of many chronic diseases responsible for organ failure. Although the...
متن کاملA new molecular target for blunting organ fibrosis. Focus on "Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention".
FIBROSIS IS A PATHOLOGY ASSOCIATED with failure of many different organs, including the heart, lung, kidney, liver, and the vasculature. Fibrosis results from wound healing (and in some cases developmental) processes that become prolonged or dysregulated. Following tissue damage, inflammation at the site of injury produces a gush of cytokines that signal subsequent myofibroblast differentiation...
متن کاملSecreted Frizzled - related protein 2 ( sFRP 2 ) as a target 2 in anti - fibrotic therapeutic intervention 3 4
22 23 24 Progressive fibrosis is a pathological hallmark of many chronic diseases responsible for 25 organ failure. Although there is currently no therapy on the market that specifically targets 26 fibrosis, the dynamic fibrogenic process is known to be regulated by multiple soluble mediators 27 that may be therapeutically intervened. The failing hamster heart exhibits marked fibrosis and 28 in...
متن کاملSecreted frizzled related protein 1 is a target to improve fracture healing.
Genetic studies have identified a high bone mass of phenotype in both human and mouse when canonical Wnt signaling is increased. Secreted frizzled related protein 1 (sFRP1) is one of several Wnt antagonists and among the loss-of-function mouse models in which 32-week-old mice exhibit a high bone mass phenotype. Here we show that impact fracture healing is enhanced in this mouse model of increas...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2014
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00238.2013